Free-Breathing, Confounder-Corrected, 3D T1 Mapping of the Liver through Simultaneous Estimation of T1, PDFF, R2* and B1+

T1 relaxation is emerging as a biomarker for the diagnosis and staging of chronic liver disease. Modified Look-Locker Inversion Recovery (MOLLI) is widely used in clinical practice for abdominal T1 mapping; however, current methods are not corrected for fat and B1 inhomogeneities as confounding factors and fail to provide reliable T1 measurements. In this work, we propose a novel, free-breathing, confounder-corrected T1 mapping method over the entire liver, by combining inversion recovery and chemical shift encoding imaging for simultaneous estimation of T1, PDFF, R2* and B1+.