What question did this study set out to answer?

To develop and validate a modified Look-Locker inversion recovery sequence capable of measuring myocardial T1 relaxation times in vivo during a single breath-hold.

June 28, 2004Magnetic Resonance in MedicineOpen Access

Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution T₁ mapping of the heart

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To develop and validate a modified Look-Locker inversion recovery sequence capable of measuring myocardial T1 relaxation times in vivo during a single breath-hold.
Merged data from three successive Look-Locker inversion recovery experiments with different inversion times into a single dataset.
Acquired images in late diastole on a 1.5 Tesla MR system using single-shot steady-state free-precession combined with sensitivity encoding, limiting acquisition windows to under 200 ms.
Evaluated sequence accuracy in phantoms across simulated heart rates, two healthy volunteers, and one patient with acute myocardial infarction before and after Gd-DTPA contrast administration.
Phantom experiments demonstrated small systematic errors across T1 values ranging from 191 to 1196 ms over varying simulated heart rates.
In vivo myocardial and noncardiac T1 measurements closely matched established literature values.
Pre- and post-contrast T1 maps clearly delineated and visualized the region of acute myocardial infarction.

Authors

DMDaniel MessroghliCardiac Imaging ARAleksandra RadjenovicLeeds General Infirmary SKSebastian KozerkeCardiac Imaging

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Implication

Methodological study demonstrates high-resolution cardiac T1 mapping within a single breath-hold in humans, highlighting enhanced detection of myocardial infarction.

Cite This Study

Messroghli et al. (2004) studied this question.

synapsesocial.com/papers/6a029d91db924cefa9fad1fc https://doi.org/10.1002/mrm.20110

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Implication

Methodological study demonstrates high-resolution cardiac T1 mapping within a single breath-hold in humans, highlighting enhanced detection of myocardial infarction.

Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution T₁ mapping of the heart

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Discussion

Implication

Cite This Study

Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution T₁ mapping of the heart

Key Points

Discussion

Implication

Cite This Study

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