Key result
The Sh-MOLLI sequence produced T1-estimates that were on average 10.2 ms (-1%) lower than the standard MOLLI sequence (p < 0.001) while requiring nearly half the acquisition time.
Why the study?
Does the Sh-MOLLI sequence provide faster cardiac T1 mapping compared to the standard MOLLI technique?
Observational (n=10)
No
Does the Sh-MOLLI sequence provide faster cardiac T1 mapping compared to the standard MOLLI technique?
Mean Difference: -10.2
p-value: p=<0.001
The Sh-MOLLI sequence provides a faster alternative for cardiac T1 mapping, addressing the limitation of long breath-holds in clinical applications.
May reduce breath-hold demands in T1 mapping; leaves open diagnostic equivalence in diverse populations.
Background T1-mapping of the myocardium can potentially detect, quantify and monitor subtle diffuse pathology without the use of contrast agent. One proven method is the MOLLI (Modified Look-Locker Inversion-recovery) technique, offering single-slice T1-mapping based on three sequential inversion-recovery (IR)-prepared experiments in a 17-heartbeat breath-hold. However, long breathholds can limit clinical application in patients. We propose and test a novel variant (Sh-MOLLI) that is approximately two times faster.
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Piechnik et al. (2010) conducted an observational in Healthy volunteers (n=10). Sh-MOLLI sequence vs. MOLLI sequence was evaluated on T1-estimates across 160 pooled myocardial segments (MD -10.2 ms, p=<0.001). The Sh-MOLLI sequence produced T1-estimates that were on average 10.2 ms (-1%) lower than the standard MOLLI sequence (p < 0.001) while requiring nearly half the acquisition time.
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