Cortical thickness and white matter integrity abnormalities in dysthyroid optic neuropathy

A pilot study to examine the structural MRI features of patients with dysthyroid optic neuropathy (DON) as compared to normal controls, and correlate pathologic MRI changes to clinical symptoms of the disease. DON patients show reduced cortical volume in precuneus and occipital pole, decrease area in precuneus and precentral gyrus, and widespread decreased FA value, mainly in genu of corpus callosuma and body of corpus callosum. Meanwhile, the FA of was associated with visual acuity. Our study provides a new insight of pathological mechanism of DON.