The effect sizes of aging in hippocampus (HPC) resting-state functional connectivity (rsFC) using dASL and multi-echo BOLD (ME-BOLD) imaging were evaluated in 20 subjects (10 young adults, 10 older adults). Both dASL and ME-BOLD showed reduced HPC rsFC in older adults but with larger extended region in dASL results. dASL demonstrated significantly higher effect sizes of aging in HPC rsFC compared to ME-BOLD, supporting more sensitivity of dASL in detecting the aging effect in HPC rsFC.
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Zhang et al. (2024) studied this question.
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