Comparison of long-label single-delay ASL and multi-delay ASL in healthy aging

Motivation: Identify the most sensitive arterial spin labeling (ASL) methods for brain aging Goal(s): Compare single- and multiple-post labeling delay (PLD) ASL protocols in healthy aging Approach: Absolute cerebral blood flow (CBF), relative CBF, and arterial transit time (ATT) from long-label (LL) single-PLD and multi-PLD sequences were correlated with age and other variables in an adult lifespan cohort. Results: Age effects were more significant in ATT and ATT-corrected CBF values than in LL single-PLD CBF, though the use of putamen-normalized relative single-PLD CBF enhanced sensitivity to age and other biological parameters. Impact: Multi-PLD ASL enhances the assessment of age effects on brain perfusion.