Key result
Arterial spin labeling reliably captures bright vessel appearance at post-labeling delays between 1525 and 2525 msec.
Why the study?
Differences in blood flow strength, vessel diameter, and post-labeling delay effects on bright vessel appearance by arterial spin labeling were unclear.
Does post-labeling delay variation affect the observation of bright vessel appearance by arterial spin labeling in physical experiments?
Does post-labeling delay variation affect the observation of bright vessel appearance by arterial spin labeling in physical experiments?
Post-labeling delay between 1525 and 2525 msec allows for the observation of bright vessel appearance in arterial spin labeling.
Phantom experiments identify feasible ASL parameters; hypothesis-generating and requires clinical validation before any protocol changes.
Objective: This study was performed to clarify the differences in blood flow strength, blood vessel diameter, and post-labeling delay (PLD) by physical experiments, and to examine whether bright vessel appearance (BVA) can be observed by arterial spin labeling (ASL). Methods: . Results: . Conclusion: PLD distinguishes spin in brain tissue from 1525 msec to 2525 msec, and it can be observed. As spin signal decreases when the flow rate is slow, attention is necessary for observation. Assessment at PLD1525-2525 msec where normal perfusion was obtained suggested that BVA can be observed.
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Chiba et al. (2020) studied Healthy/Normal perfusion (Phantom experiment) (n=20). Post-labeling delay (PLD) variation in Arterial Spin Labeling (ASL) vs. Different PLDs, flow rates, and tube diameters was evaluated on Signal intensity of blood (SIblood) compared to brain tissue (SItissue). In a phantom experimental model, the signal intensity of simulated blood significantly exceeded that of brain tissue at post-labeling delays of 1525 to 2525 msec, suggesting that bright vessel appearance can be effectively observed using arterial spin labeling MRI.
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