Improved reproducibility of GABA measurement in short-TE 1H MRS by linewidth-matched basis sets

This study investigated the spectral linewidth effect on GABA quantification, as well as its correction approach in LCModel with both simulated and in vivo acquired 1H MR spectra. Using the same basis set to fit spectra with different linewidths results in elevated variations between measurements. An effective method to reduce the variability caused by the linewidth difference effect and more accurately quantify GABA is to use spectral-linewidth-matched basis sets. This study shows the validity of this approach for most of the Voigt-type spectra.