Changes in total glutathione (GSH) level in left anterior cingulate cortex (ACC) following lithium monotherapy of bipolar disorder in depressed state were studied at7T. Patients were scanned with a semi-LASER sequence at baseline and 2, 8 and 26 weeks from onset of therapy. Healthy controls were also scanned at those 4 time points. An increase in GSH level at left dorsal/rostral ACC was observed in patients, and the increase took place between 8 and 26 weeks after the start of therapy.
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Bhattacharyya et al. (2024) studied this question.
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