A 3D pipeline (longitudinal registration followed by cluster analysis) was developed to identify focal-lesions (clusters) of elevated T2 and T1ρ in femoral cartilage over 4-visits (3-weeks, 3, 9, and 18-months) post ACL-reconstruction surgery. Cluster Average (CA) and Cluster Percentage (CP) for T2 were significantly higher for ACL-inured when compared to ACL-contralateral and control-healthy knees. While the CP followed an increasing trend during subsequent visits, CA did not significantly vary across visits. Thus, our method could be effective for identifying and tracking quality (measured by CA) and quantity (measured by CP) of focal lesions in ACL-injured population.
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S et al. (2024) studied this question.
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