A multiscale approach based on the combination of DTI, XRD and histology to study the myeloarchitecture in a rat model of mTBI

We have combined high-resolution structural imaging techniques, such as scanning micro-X-ray diffraction (SμXRD), DTI and histology to study the myeloarchitecture in both healthy and pathological rat brains. For the latter, we focused on an animal model of mild traumatic brain injury (mTBI) that is the most common form of acquired brain injury caused by an external force into the brain. We have performed a quantitative morphometrical analysis of myelin, mapping its relevant morphological and topological parameters (period, orientation, and integrated intensity fluctuation) to assess tissue microstructural damage 35 days after mTBI and sham-operation