Intrinsic CSF outflow declines with age in healthy humans detected by spin-labeling MRI

Parasagittal dura (PSD) along the superior sagittal sinus (SSS) can be visualized using FLAIR and 3D SSFSE without gadolinium-contrast administration. Visualization of intrinsic CSF outflow from the PSD to the SSS can be achieved in human brains using spin-labeling MRI at clinical 3-T MRI. The spin-labeling MRI shows intrinsically tagged CSF outflow from the upper PSD and lower PSD to SSS. The quantitative intrinsic CSF outflow metrics indicate an age-related decline of the intrinsic CSF outflow at the SSS in human brains.