Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults

Kilian Hett; Colin D. McKnight; Jarrod Eisma; Jason Elenberger; J. Suzanne Lindsey; Ciaran Considine; Daniel O. Claassen; Manus J. Donahue

doi:10.1186/s12987-022-00320-4

March 21, 2022SHILAP Revista de lepidopterologíaOpen Access

Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults

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Key Points

To evaluate the feasibility of non-invasively measuring parasagittal dural space (PSD) volume and examine its relationship with age and cerebrospinal fluid (CSF) flow across the healthy adult lifespan.
Utilized non-contrast MRI combined with machine learning algorithms to quantify PSD volume non-invasively in vivo.
Evaluated associations between PSD volume, age, total CSF volume, and bidirectional CSF flow in a cohort of healthy adults.
Demonstrated the feasibility of machine learning-assisted quantification of PSD volume from non-contrast MRI scans.
Found that PSD volume increases with age and relates directly to CSF volume and bidirectional CSF flow dynamics.
Established normative reference ranges across the adult lifespan to serve as baselines for identifying alterations in neurodegenerative disorders.

Implication

Neuroimaging analysis shows parasagittal dural space volume increases with age and correlates with CSF flow in healthy adults, providing normative baselines for neurodegenerative diseases.

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Cite This Study

Hett et al. (2022) studied this question.

synapsesocial.com/papers/69da596bae64bec32b835a05 https://doi.org/10.1186/s12987-022-00320-4

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Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults

Key Points

Implication

Abstract

Discussion

Cite This Study

Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults

Key Points

Implication

Abstract

Discussion

Cite This Study

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