Cerebral waste clearance reduces with healthy aging and occurs in various neurodegenerative diseases. Both perivascular spaces (PVS) and the parasagittal dural (PSD) space play important roles in waste clearance, where the former transports waste products through the parenchyma, the latter is associated with cerebrospinal fluid efflux from the cranial compartment. The current 7T MRI study investigated sex differences in the relation between PVS and PSD volume in an elderly sample. By identifying a relationship between PVS and PSD solely in females, this study illustrates the possibility of a different impairment mechanism of the clearance system between elderly men and women.
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Thiel et al. (2024) studied this question.
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