Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7T

31P diffusion magnetic resonance spectroscopy could assess the diffusion properties of high energy metabolites. In this study, a diffusion weighted (DW) STEAM sequence was implemented, and spectra were acquired in the human calf muscle of six healthy volunteers. Frequency and phase alignments were applied prior to spectral averaging. The ADC of phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi) and glycerol phosphorylcholine (GPC) were (0.24±0.02, 0.15±0.04, 0.43±0.14, 0.40±0.09)×10-3 mm2/s. To the best of our knowledge, this is the first study reporting the ADCs of ATP, Pi, and GPC, and the second study reporting the ADC of PCr in human.