31P topical magnetic resonance is a reliable method for estimating free metabolite concentrations in human muscle, offering advantages over chemical estimates.
Offers non-invasive metabolite research tool in normals; leaves open clinical translation without disease-state validation.
The results we have obtained on forearm muscles of normal human subjects are complementary to those on isolated frog muscle and they lead, to the same conclusions. We are satisfied that our31P TMR measurements of [P-metabolites] in normal subjects are reliable, and we are now extending these methods for use in cases of degenerative muscular disorders (Edwards et al., 1982). Chemical estimates of [ADP] and [AMP] are not directly relevant to metabolic studies, and so an important contribution of NMR to the study of muscular mechanisms is its ability to estimate the concentrations of these metabolites that are free to take part in metabolic reactions.
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M. Joan Dawson (1982) studied this question.
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