Comparing brain amyloid load using PET to grey matter perfusion using ASL on the OASIS-3 dataset

Alzheimer’s disease (AD) is the leading cause of dementia, and it is associated with cerebral amyloid beta accumulation and changes in cerebral perfusion. Amyloid PET imaging can be used to measure the amyloid beta load, while ASL-MRI is preferred for cerebral perfusion measurements, which may occur before amyloid beta accumulation. This study compares the amyloid beta load with the CBF in grey matter, in both cognitively healthy and cognitively impaired subjects from the OASIS-3 dataset. A logistic regression model using this data was able to classify the cognitive status of subjects with a 78.48% test accuracy.