A 3D downfield-MRSI sequence with whole brain coverage, 22-minute scan time, and 0.7 cm3 nominal spatial resolution has been developed at 3T. The sequence was tested in 5 normal volunteers; LCModel analysis showed CRLB average values of 3-4% for protein amide resonances in 3 selected gray and white matter regions.
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Özdemir et al. (2024) studied this question.
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