Dynamic co-fluctuation patterns of fMRI brain activity in temporal lobe epilepsy

Temporal lobe epilepsy (TLE) presents with transient epileptic activity at rest, typically originating from the hippocampus. Here we measure dynamic functional connectivity (FC) at single functional MRI timepoints with edge timeseries to detect recurring hippocampal co-fluctuation patterns and their alterations in TLE. Three anterior hippocampus co-fluctuation patterns were detected in healthy controls. One pattern was altered in TLE, while another pattern was more frequent in TLE than controls. These changes reflect alterations in dynamic spatial patterns of FC from the epileptic focus in TLE.