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Investigating Atypical Neural Dynamics and Gene Expression in Temporal Lobe Epilepsy: Insights From Co‐Activation Patterns

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Patients with temporal lobe epilepsy exhibit atypical neural dynamics and significant gene expression changes.
Dynamic indicators of co-activation patterns correlate with cognitive performance in epilepsy patients.
Analysis revealed 2752 genes associated with atypical brain states, primarily linked to synaptic pathways.
Findings deepen the understanding of neurobiological mechanisms behind temporal lobe epilepsy.

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This study uncovers differences in brain activity and gene expression in temporal lobe epilepsy, highlighting links to cognitive impairment.

Qin et al. (2025) studied this question.

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This study uncovers differences in brain activity and gene expression in temporal lobe epilepsy, highlighting links to cognitive impairment.