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The study aims to investigate abnormal brain network hierarchies in temporal lobe epilepsy and their molecular correlates.

March 31, 2026Neurobiology of DiseaseOpen Access

Revealing brain network hierarchy and molecular correlates in temporal lobe epilepsy: A multimodal neuroimaging study

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The study aims to investigate abnormal brain network hierarchies in temporal lobe epilepsy and their molecular correlates.
Analyzed multimodal MRI data for connectivity gradients and structural decoupling.
Assessed cognitive function using the Attention Network Test (ANT).
Explored gene expression data for molecular correlations from the Allen Human Brain Atlas.
TLE patients exhibited disrupted functional gradients while structural gradients remained stable.
Abnormalities were observed in the Default Mode Network across all imaging modalities.
Functional core-periphery dissociation was identified in rich-club analysis along with structural convergence.

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Multimodal neuroimaging reveals brain network abnormalities in temporal lobe epilepsy, indicating significant cognitive implications.

Su et al. (2026) studied this question.

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