Functional Abnormalities of Cerebellum in Vascular Cognitive Impairment

The potential prevalence of vascular cognitive impairment (VCI) is high; early diagnosis and treatment is essential for disease prognosis. In this study, compared to healthy controls (HCs), there were differences of functional connectivity (FC) between the cerebellum and cerebral regions of VCI patients, mainly involving default mode network (DMN), sensorimotor network (SMN) and frontoparietal network (FPN). Furthermore, FC between multiple sub-regions in the cerebellum reduced in patients with VCI compared to HCs. These findings may expand our understanding of the neural mechanisms of VCI in the perspective of neurovascular coupling.