Major depressive disorder (MDD) is a severe mental disorder with unclear pathophysiology mechanism. The present study aimed explore white matter (WM) microstructure alterations in MDD patients using synthetic MRI technique. The results showed shorter T1 relaxation time in several deep WM regions, while extensive myeline content was found in left anterior limb of internal capsule in patients with MDD. Thus, we concluded that WM alterations caused by MDD can be revealed by quantitative MRI parameters.
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Wen et al. (2024) studied this question.
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