Choroid plexus volume can predict dementia conversion in non-dementia older subjects

Prediction or prevention of progression to dementia for non-demented patients is critical for management and prevention strategy of dementia. Recent evidences suggest that larger choroid plexus (CP) volume was associated with the severity of cognitive impairment in Alzheimer disease (AD) spectrum. We evaluated clinical data and the volume, permeability and susceptibility of choroid plexus of 62 consecutive non-demented prospective cohorts with follow-up up to 2 years. Dementia converter group showed larger CP volume than that of non-converters. Thus, CP volume could be utilized as a potential imaging marker for patients who are likely to progress to dementia.