Histogram-based analysis of recurrence pattern correlations with MGMT methylation status in glioblastoma using synthetic MRI and 3D-ASL

At least 10% of glioblastoma relapses occur at distant and even contralateral locations. This disseminated growth limits surgical intervention and contributes to neurologicalmorbidity. The aim of the present study was to evaluate factors predicting the recurrencepattern determined. The results revealed that the pattern of recurrence in glioblastoma patients after combined radio-chemotherapy treated are strictly correlated with age at diagnosis and MGMT methylation status. Whole-tumor histogram analysis of quantitative parameters from synthetic MRI and 3D-ASL was to evaluate the value of predicting MGMT methylation status. Combining T110th, T210th ,and CBFentropy may explore as an effective strategy to predict of MGMT methylation status.