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IDH wild-type glioblastoma: Predictive value of standard-of-care (SOC) MRI for establishing MGMT promoter methylation status

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Retrospective analysis shows MRI markers predict MGMT methylation status in glioblastoma, indicating potential for personalized treatment strategies.

A thick enhancing tumoral margin is present in 67.3% of MGMT unmethylated glioblastomas, indicating its potential role in prognosis.
Tumoral cortical extension occurs in 68.7% of unmethylated cases versus 31.3% in methylated ones, suggesting it may indicate worse outcomes.
Non-enhancing tumors predominantly show MGMT methylation (83.3%), indicating that specific MRI characteristics could guide treatment decisions.
Higher progression-free survival rates were identified in patients with MGMT methylation and without cortical tumoral extension, emphasizing the importance of MRI findings.

Khalaj et al. (2025) studied this question.

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Retrospective analysis shows MRI markers predict MGMT methylation status in glioblastoma, indicating potential for personalized treatment strategies.