Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Neurosurgical FOCUSOpen Access

The role of extent of resection, chemoradiation, and MGMT promoter methylation in overall survival in a large cohort of IDH-wildtype glioblastoma

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMegan ParkerJohns Hopkins UniversityACAustin CarmichaelJohns Hopkins UniversityASAntolin Serrano-FariasJohns Hopkins University

Discussion

Loading...

Member takes

Implication

Observational analysis shows that MGMT promoter methylation and extent of resection improve survival in glioblastoma, suggesting implications for treatment planning.

Key Points

  • Maximizing the extent of resection notably improves overall survival in glioblastoma patients.
  • In multivariate analysis, gross-total resection is associated with a 40% improvement in survival compared to excisional biopsy.
  • Chemotherapy and MGMT promoter methylation both independently enhance survival rates among individuals with glioblastoma.
  • The influence of gross-total resection on survival in MGMT methylated tumors receiving chemoradiation requires further research.

Cite This Study

Parker et al. (2025) studied this question.

synapsesocial.com/papers/68c1a90c54b1d3bfb60e22c1https://doi.org/10.3171/2025.5.focus25350
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preoperative prediction of MGMT promoter methylation in glioblastoma based on multiregional and multi-sequence MRI radiomics analysis2024 · 27 citations
  2. 2A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival2001 · 3,128 citations
  3. 3Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM2021 · 61 citations
  4. 4Extent of MGMT Promoter Methylation Modifies the Effect of Temozolomide on Overall Survival in Patients with Glioblastoma: A Regional Cohort Study2022 · 8 citations
  5. 5Impact of maximal extent of resection on postoperative deficits, patient functioning, and survival within clinically important glioblastoma subgroups2022 · 65 citations