In vivo primary sensorimotor cortex glutathione does not differ in autistic children

Redox imbalance has been suggested as a pathophysiological factor in autism spectrum disorder (ASD). Edited MRS can be used to measure levels of glutathione, the most abundant redox compound in the brain. This study aims to compare glutathione levels in autistic children and typically developing children (TDC). Edited data were collected from the primary sensorimotor cortex (SM1) in 34 children with ASD and 31 TDC and quantified using Osprey. No difference was found in GSH levels in the SM1 between these two groups.