The aging progress of neuron is characterized by degenerative changes of structure and function. Few studies have focus on the structure in cellular level. In this study, we quantified cell size and cellularity in globus pallidus, putamen and substantia nigra pars compacta using time dependent diffusion imaging. Subgroup analysis by age showed the increased intracellular volume fraction of putamen in older people while diameter does not change over age. These findings might demonstrate the potential of MRI cell size imaging to assess the degeneration of neuron on cellular level.
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Chen et al. (2024) studied this question.
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