Investigating the impact of ketogenic diet in Alzheimer’s disease using 1H MRS

Ketogenic diet (KD) may be used to treat cognitive dysfunction in Alzheimer’s disease (AD). In hAPPJ20 AD mice fed KD, improved spatial learning has been noted, but mechanisms driving this cognitive change remains unclear. Here we used 1H MRS to probe the effect of KD on brain metabolism in hAPPJ20 mice fed either a control diet or KD. Increases in prefrontal creatine and Glx in KD-fed mice and increased Tau in male KD-fed mice were observed. Male KD-fed mice also demonstrated better spatial learning on the Morris water maze. Thus, KD may improve brain energetics and neurotransmission supporting cognitive function.