Cross-sectional study demonstrates normative brain volume decline and hemispheric asymmetry in healthy individuals, highlighting baseline trajectories for diagnostic quantification.
Cross-sectional neuroimaging studies have indicated hemispheric asymmetry, gender differences and a decline in brain volume with advancing age. However, these studies often have a small sample size (≤ 500) and unbalanced groupings, resulting in contradictory findings that might not be reproducible. Precise estimates on a large cohort will facilitate the assessment and quantification of brain volume, resulting in improved diagnostics and establishing statistical norms. In this study we analyze 6739 individuals to draw normative conclusions about typical patterns of age-related brain changes. We provide whole-brain and regional volume aging-curves for males and females for raw and head-size adjusted data.
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Akbari et al. (2024) studied this question.
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