Studying variation in DWI MRI derived ADC for Prostate Cancer (PCa) with respect to Gleason Grade and location of PCa lesions

Diffusion weighted MRI (DWI) derived apparent diffusion coefficient (ADC) is a marker of the extent of restrictive diffusion in tissues. Higher Gleason Grade (GG) prostate cancer (PCa) lesions are known to exhibit higher restrictive diffusion. In this study we investigated whether ADC as a tissue biomarker follows the known histopathological behavior of PCa lesions by studying variations in ADC with respect to GG of PCa lesions and its location. We observe that ADC values of lesion voxels, although belonging to same GG, vary based on its location.