Metabolic imaging techniques such as mass spectrometry imaging (MSI) complement magnetic resonance spectroscopy and colocalize metabolite profiles with immunohistological evaluation of tissue sections. Here we have performed matrix-assisted laser desorption/ionization (MALDI)-MSI of normal pancreatic tissue, intraductal papillary mucinous neoplasm (IPMN), and pancreatic ductal adenocarcinoma (PDAC) to characterize the spatial distribution of PDAC metabolites in tissue sections. Our preliminary data with MALDI-MSI identifies significantly increased taurine and significantly decreased creatine, both of which can also be detected with 1H MRS, in PDAC compared to normal tissue. The spatial heterogeneity of metabolite distribution in PDAC tissue can be related to immunohistochemical evaluation.
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Yousf et al. (2024) studied this question.
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