Our group recently reported a method for direct imaging of neuronal activity (DIANA), suggesting that its contrast mechanism is T2 changes due to changes in membrane potential during neuronal activation, which accompanies cell swelling and changes in hydrating water modlecules of the cell membrane. In this study, by measuring apparent-diffusion-coefficient (ADC) and pool-size-ratio (PSR) versus T2, respectively, we verified the respective contribution of cell swelling and changes in hydrating water modlecules to T2 changes when only osmotic pressure or membrane potential was altered in T-lymphocyte cells in vitro.
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Kim et al. (2024) studied this question.
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