Whole-brain connectivity in patients with Pediatric Cerebellar Ataxia

For the first time, brain networks of pediatric cerebellar ataxic patients were characterized in order to explain the different postural motor behavior of subjects suffering from non-progressive and slow-progressive illness. This work revealed volume differences in several cerebellar regions and specific alterations of white matter tracts. This result reinforces the hypothesis of the existence of a compensatory strategy which may involve cortical areas and basal ganglia to compensate for cerebellar deficits.