fMRI in rats is performed under diverse protocols that span different animal handling practices and preprocessing steps. The disparity in image acquisition and preprocessing hampers the interoperability and comparison of the results between studies. Importantly, it is unclear what factors lead to superior acquisition and detection of functional networks. We detail a consensus-based task-free fMRI acquisition protocol in the rat that has been validated in 21 datasets. Along with the animal handling protocol and MRI sequence, we provide a detailed path for data conversion, preprocessing, and analysis.
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Vrooman et al. (2024) studied this question.
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