Brain connectome-based imaging markers for identifiable signature of migraine with and without aura

In comparison with migraine without aura (MwoA), migraine with aura (MwA) has its own characteristics in symptom, pathological mechanism, treatment and prognosis. In this study, we conducted connectome-based analysis to capture brain connectivity markers that would show identifiable signature of MwA and MwoA, using diffusion tensor imaging and resting-state functional MRI. We found that the alterations of structural and functional connectivity strength contributed to migraine patient subtyping. The whole brain connectome-based imaging markers might provide possible evidence in understanding the heterogeneity of migraine with aura and help for patient-specific decision.