Microstructural neurodegeneration of the entorhinal-hippocampus pathway in preclinical Alzheimer’s disease: ex vivo 11.7T MRI and histology

Conventional neuroimaging biomarkers for the neurodegeneration of Alzheimer’s disease (AD) are not sensitive enough to detect neurodegenerative alterations in preclinical AD individuals. We aimed to examine microstructural neurodegeneration of the entorhinal-hippocampus pathway during the pathological process of AD. Our ex vivo comparative study of 11.7T MRI and histology successfully visualized microstructural neurodegeneration of the entorhinal-hippocampus pathway in preclinical AD brain tissues. In a future study, we aim to translate the findings from ex vivo 11.7T MRI and histology into in vivo MRI clinical research for preclinical AD individuals.