Fluid mechanics based distinct cerebrospinal fluid dynamics signature in normal pressure hydrocephalus

Normal pressure hydrocephalus (NPH) is a brain pathology with enlarged ventricles and is diagnosed as a cerebrospinal fluid (CSF) dynamics disorder based on a delayed ascent of radiotracer over the cerebral convexity and elevated flow through the cerebral aqueduct. In this study, we provide fluid dynamics-based evidence of disruption in CSF oscillation within the cerebral aqueduct in NPH patients. Particularly, we show that the peak volumetric flow is delayed with respect to peak transmantle pressure in NPH patients as compared to healthy control participants.