Repeated Electroconvulsive Shock does not Affect Cognition and Neurometabolism in Mouse Brain

Electroconvulsive therapy is an effective treatment for chemo-resistant depression. The impact of electroconvulsive shock (ECS) on cognition and neurometabolism is not clear. The memory of mice was evaluated using Y-maze test. The rates of glucose oxidation (CMRGlc(ox)) were measured by 1H-[13C]-NMR spectroscopy together with an infusion of [1,6-13C2]glucose after 24 hours and 3 months of the repeated ECS. The spontaneous alternation was decreased after 24 h and 1 month of repeated ECS, and was restored after two months. The CMRGlc(ox) was reduced in PFC after 24 h of ECS. These changes were normalized after 3 months of ECS.