Altered Hippocampal Subregions Volumes Is Associated With Emotional Impairment of Parkinson’s Disease

Depression is the main emotional manifestation associated with Parkinson's disease. The hippocampus is a core region in the limbic system, critical in regulating emotion. This study explored the subregional atrophy pattern of the hippocampus in Parkinson's disease with depression (DPD) patients and its correlation with the severity of depressive symptoms. The results of this study suggest that DPD patients exhibit a left asymmetric atrophy pattern in the hippocampus and its subregions. Partial correlation analysis showed that the left dentate gyrus, left molecular layer, left CA4 and left hippocampal volumes were negatively correlated with Hamilton depression scale scores in DPD patients.