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Depressive symptoms are common in Parkinson’s disease (PD), but the pathophysiology and neural basis underlying depression in PD is complex. To shed more light on the abnormal regions and distribution characteristics of gray matter in PD patients with depression (DPD), we conducted a Voxel-Based Morphometry (VBM) study. Compared with PD with non-depression (NDPD) patients, the gray matter volume of DPD patients decreased abnormally in the right superior temporal gyrus, right inferior temporal gyrus, left orbital superior frontal gyrus and left dorsolateral superior frontal gyrus. We speculate that changes in the brain regions are essential in the pathophysiology of DPD.
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Cao et al. (2024) studied this question.
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