Alterations of white matter connectivity in essential tremor with MR-guided focused ultrasound thalamotomy

This is important research to assess the effects of MRgFUS thalamotomy on white matter connectivity in ET. Results showed that MRgFUS might act the topologic properties on brain networks. Rich-club and small-world organizations exist in HC and ET. The right orbital part of the superior frontal gyrus and right putamen were identified as a hub in the ET group only, whereas the left putamen identified as hubs in the group only. Importantly, gamma and sigma correlated tremor improvement after MRgFUS thalamotomy, playing a role in reflecting tremor improvement for clinical treatment.