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Arterial-spin-labeling (ASL) MRI has been widely used in neurological studies for investigating brain activity via focusing on regional perfusion differences. However, sensitivity is a general issue in ASL MRI to prevent the high-resolution comparisons of perfusion heterogeneity, which are associated with pathological process, or lead to prolonged scan time, which inhibits the temporal resolution in monitoring acute-stage perfusion changes (e.g., perfusion recovery after spontaneous resuscitation in cardiac arrest). Therefore, in this study, a post-processing method exploring spatiotemporal redundant information of ASL data is proposed to enhance the sensitivity without extending scan durations.
Chen et al. (Wed,) studied this question.