Spatiotemporal redundancy based denoising method in arteprial spin labeling MRI: A ticket to free sensitivity improvement

Arterial-spin-labeling (ASL) MRI has been widely used in neurological studies for investigating brain activity via focusing on regional perfusion differences. However, sensitivity is a general issue in ASL MRI to prevent the high-resolution comparisons of perfusion heterogeneity, which are associated with pathological process, or lead to prolonged scan time, which inhibits the temporal resolution in monitoring acute-stage perfusion changes (e.g., perfusion recovery after spontaneous resuscitation in cardiac arrest). Therefore, in this study, a post-processing method exploring spatiotemporal redundant information of ASL data is proposed to enhance the sensitivity without extending scan durations.