A dynamic contrast-enhanced MRI (DCE-MRI) protocol was optimized to measure transmembrane water exchange rate (kio), which was correlated kio with aquaporin-4 (AQP4) immunohistochemistry results in a rodent subcutaneous glioma model. From the acquired results, a significant correlation was demonstrated between the optimized kio and AQP4, indicating that kio measured by DCE-MRI could reveal the expression of AQP4.
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Han et al. (2024) studied this question.
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