Staphylococcus aureus is of particular concern due to the deaths associated with antimicrobial resistance and the emergence of antibiotic-resistant strains. There is not currently a vaccine as translation from preclinical models to humans has been unsuccessful. Acquiring reproducible and comparable spinal images that offer non-invasive visualization of the extent and impact of the infection are important for successful intervention or vaccine development. 3D-printed, MRI-compatible cradles enable reproducible positioning and analysis for both in vivo and ex vivo MR spinal imaging in mouse models while allowing for nondestructive analysis of the potential additional benefits to visualization associated with ex vivo MEMRI.
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Goldman et al. (2024) studied this question.
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