Based on animal and human lesion studies, isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) is due to changes in arousal/motor brainstem nuclei structure and function and is recognized as the hallmark of Parkinson disease (PD). Resting-state fMRI studies in iRBD in humans mostly studied changes in nigrostriatal/nigrocortical connectivity pathway but failed to assess the brainstem circuits involved. To fill this gap, we investigated the functional connectivity of 20 brainstem nuclei relevant for iRBD using high-sensitivity and high spatial-resolution 7 Tesla resting-state fMRI, as well as a recently developed in-vivo probabilistic atlas of brainstem nuclei.
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Singh et al. (2024) studied this question.
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