High Temporal Resolution Blood Oxygen Level Dependent functional MRI.

We demonstrate the feasibility and robustness of a new method to measure blood-oxygen-level-dependent functional MRI(BOLD-fMRI) signals at high temporal resolutions(up to 250ms). Whole-brain data at 1x1x1 mm3 were acquired uninterruptedly during a blocked-design ON/OFF visual paradigm(checkerboard vs. grey image). Images were reconstructed with a 4D x-y-z-t dimensions at 2.5s, 1.0s, 500ms and 250ms temporal resolution, allowing to retrieve the expected %signal change(2%) in visual cortices. We also evaluated the effect of compressed-sensing(CS) application in BOLD-fMRI reconstruction schemes, finding that CS improves the obtained signal in the calcarine sulcus(around 23k(a.u) in pixel intensity of BOLD map TCFE corrected vs 10k(a.u)).