Multiparametric MRI assessment of botulinum-toxin treatment for a patient with cervical dystonia

Cervical dystonia (CD) has been regarded as the most common form of focal dystonia, the affected neck muscles always in sustained situation lead to an abnormal rotation of the head[1]. The mechanisms of CD have not yet been thoroughly illustrated. Botulinum toxin (BT)is considered as the recommended first-line therapeutic method for the focal dystonia[2]. Traditional MRI Scan has been used to evaluate any pathophysiological changes of brain anatomy or the affected neck muscles[3]. However, seldom MRI have provided the cervical muscles metabolic messages[4]. The CEST MRI could provide the metabolic aspects of the cervical muscles before and after the treatment of the BT