Study of Oxidative Stress due to X-ray Irradiation in Mouse Brain using TOLD MRI Imaging

This study aims to evaluate the metabolic changes caused on the brain tissues due to radiation exposure to healthy tissues while tumor treatment. The tissue oxidization and reduction mechanism represented by redox imaging could be a suitable index to evaluate in vivo oxidative stress in living animals that could evaluate metabolic damages due to irradiation. We adopted tissue oxygen level dependent (TOLD) MRI imaging to analyze TOLD signal for the control group mice and the irradiated mice. The result shows the distinct oxygen consumption levels in the control and the irradiated mice.